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Gastroenterology

Celiac Disease

Celiac disease is a chronic intestinal disease caused by intolerance to gluten. It is characterized by immune-mediated enteropathy, associated with maldigestion and malabsorption of most nutrients and vitamins. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes. The main symptoms are: stomach pain, gas, and bloating, diarrhea, weight loss, anemia, edema, bone or joint pain. Prevalence for clinically overt celiac disease varies from 1:270 in Finland to 1:5000 in North America.

Since celiac disease can be asymptomatic, most subjects are not diagnosed or they can present with atypical symptoms. Furthermore, severe inflammation of the small bowel can be present without any gastrointestinal symptoms. The diagnosis should be made early since celiac disease causes growth retardation in untreated children and atypical symptoms such as infertility or neurological symptoms.

In addition, tissue-transglutaminase antibodies are important to confirm the diagnosis, since there are other diseases which can mimic celiac disease. The exact cause of celiac disease is unknown but is thought to be primarily immune mediated (tissue-transglutaminase autoantigen); often the disease is inherited. Management consists in the lifelong avoidance of dietary gluten, which leads to significant clinical and histological improvement. However, complete normalization of histology can take years.

IMTEC-t-Transglutaminase Antibodies IgA
ELISA for the Quantitative Determination of Anti-tissue-Transglutaminase-Antibodies (IgA) | 96 Tests ITC30405.
IMTEC-t-Transglutaminase Antibodies IgG
ELISA for the Quantitative Determination of Anti-tissue-Transglutaminase-Antibodies (IgG) | 96 Tests ITC30305
IMTEC Gastro-LIA
Line Immuno Assay (LIA) for the Detection of Antibodies in gastrointestinal Dieases (IgA and IgG) (Gliadin, tTG, mannan, intrinsic factor) | 24 Tests ITC30701
IMTEC-d-Gliadin Antibodies IgG
ELISA for the Quantitative Determination of Anti-d-Gliadin-Antibodies (IgG) | 96 Tests ITC30505
IMTEC-d-Gliadin Antibodies IgA
ELISA for the Quantitative Determination of Anti-d-Gliadin-Antibodies (IgA) | 96 Tests ITC30605
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