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Rheumatology

Rheumatism

Connective Tissue Diseases & Rheumatoid Arthritis – The Staged Multimarker Concept

Pain in joints and muscles, stiff knees, back pain, swollen and red joints comprise the typical symptoms associated with the generic term "rheumatism". A total of about 450 different diseases are grouped together under this term. Their commonality is pain. In Germany about 20 million people suffer from the various forms of this disease. Rheumatic diseases can affect joints and/or the connective tissue. Because of the incredible diversity of rheumatic diseases these are divided into two major groups:

  • Connective tissue diseases
  • Rheuma / rheumatism

The classification presented here is only one possible structuring, but is widespread. However, the nomenclature and classification of rheumatic diseases are not uniformly regulated.

Connective Tissue Diseases

Connective Tissue Diseases are a group of rare autoimmune diseases in which the immune system recognizes parts of the body's connective tissue (collagen) as foreign, and initializes antibody production against them. Since the connective tissue is of mayor importance in many different organs,collagenosis often occurs in many organs at once, such as the skin, mucous membranes, lungs, heart or blood vessels - all of which are attacked simultaneously.

The disease course is usually chronic and can affect all physiological aspects of the afflicted patients. Women are diagnosed much more frequently than men, and the disease usually occurs in middle age.

Rheumatoid Arthritis – The Staged Multimarker Concept

An early diagnosis of rheumatoid arthritis (RA) can prevent the loss of mobility and the destruction of the joints. The usual serodiagnosis of RA (rheumatoid factor and CRP) alone is not sufficient, however, since rheumatoid factors are unspecific (and may also be evidence of other autoimmune disorders and infections). On the other hand, antibodies against cyclic citrullinated peptide (CCP) are almost exclusively present in patients with rheumatoid arthritis (specificity up to 98%). Up to 30% of early RA patients are RF and / or CCP seronegative.

Here the detection of anti-RA33 antibodies allows the diagnosis of these patients and may permit a mild disease course with less damage to joints. Regardless of anti-CCP and RF, anti-RA33 antibodies are present in the early phase of RA and can be recognized years before the clinical onset of the disease. A combined diagnosis with three serological markers offers optimal diagnostic sensitivity.

Rheumatoid Arthritis – The Staged Multimarker Concept

IMTEC-RF Screen
ELISA for the Quantitative Determination of Rheumatoid Factors (Ig(GAM)) | 96 Tests ITC60000
IMTEC-RF IgM
ELISA for the Quantitative Determination of Rheumatoid Factors (IgM) | 96 Tests ITC60003
IMTEC-RF IgG
ELISA for the Quantitative Determination of Rheumatoid Factors (IgG) | 96 Tests ITC60007
IMTEC-RF IgA
ELISA for the Quantitative Determination of Rheumatoid Factors (IgA) | 96 Tests ITC60010 
IMTEC-CCP-Antibodies
ELISA for the Quantitative Determination of Antibodies against Cyclic Citrullinated Peptide (IgG) | 96 Tests ITC60021
IMTEC-RA33-Antibodies
ELISA for the Quantitative Determination of Anti-RA33-Antibodies (IgG) | 96 Tests ITC60015

Connective Tissue Diseases

IMTEC-ANA Screen
ELISA for the Quantitative Determination of Antinuclear Antibodies (Ig(GAM)) | 96 Tests ITC60001
IMTEC-ANA Screen (cut-off)
ELISA for the Determination of Antinuclear Antibodies (IgG) | 96 Tests ITC70001
IMTEC-ENA Screen
ELISA for the Quantitative Determination of Extractable Antinuclear Antibodies (IgG) | 96 Tests ITC60005
IMTEC-ENA Screen (cut-off)
ELISA for the Detection of Anti-ENA-Antibodies (IgG) | 96 Tests ITC70005 
IMTEC-ANA/ENA Combi Screen (cut-off)
ELISA for the Detection of ANA and Anti-ENA-Antibodies (Ig(GAM)) | 96 Tests ITC70000
IMTEC-ENA Profile
ELISA for the Detection of Anti-ENA Antibodies (IgG) | 96 Tests ITC60033
IMTEC-dsDNA-Antibodies
ELISA for the Quantitative Determination of Anti-dsDNA Antibodies (IgG) | 96 Tests ITC59001
IMTEC-Anti-C1q-Antibodies
ELISA for the Quantitative Determination of Anti-C1q Antibodies (IgG) | 96 Tests ITC59033
IMTEC-ssDNA-Antibodies
ELISA for the Quantitative Determination of Anti-ssDNA Antibodies (IgG) | 96Tests ITC59005
IMTEC-Nucleosome-Antibodies
ELISA for the Quantitative Determination of Anti-Nukleosom Antibodies (IgG) | 96 Tests ITC59002 
IMTEC-SS-A/Ro-Antibodies
ELISA for the Detection of Anti-SS-A/Ro Antibodies (IgG) | 96 Tests ITC70026
IMTEC-SS-B/La-Antibodies
ELISA for the Detection of Anti-SS-B/La Antibodies (IgG) | 96 Tests ITC70024 
IMTEC-SmD1-Antibodies
ELISA for the Quantitative Determination of Anti-SmD1 Antibodies (IgG) | 96 Tests ITC60029
IMTEC-U1-SnRNP Antibodies
ELISA for the Detection of Anti-U1-SnRNP Antibodies (IgG) | 96 Tests ITC70022
IMTEC-Histone-Antibodies
ELISA for the Quantitative Determination of Anti-Histon Antibodies (IgG) | 96 Tests ITC60031
IMTEC-Scl70-Antibodies
ELISA for the Detection of Anti-Scl 70 Antibodies (IgG) | 96 Tests ITC70028 
IMTEC-Jo1-Antibodies
ELISA for the Detection of Anti-Jo1 Antibodies (IgG) | 96 Tests ITC70025
IMTEC-ANA-LIA-Maxx
Line Immuno Assay for simultanous Detection of 17 Antinuclear Antibodies (IgG) | 24 Tests ITC92005
IMTEC-ANA-LIA
Line Immuno Assay for simultanous Detection of 11 Antinuclear Antibodies (IgG) | 24 Tests ITC92000
IMTEC-Myositis-LIA PL
Line Immuno Assay for simultanous Detection of Jo1, Mi2, PM-Scl, U1-snRNP, Ku (IgG), PL-7, PL-12 | 24 Tests ITC60201
IMTEC-HISTONE-Antibodies
Histone | IgG ITC60031 
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Get in touch

  • 84 Tufnell Drive, Kamwokya, Kampala, Uganda.
  • +256 414 680 123
  • +256 750 555 505
  • This email address is being protected from spambots. You need JavaScript enabled to view it.
  • This email address is being protected from spambots. You need JavaScript enabled to view it.

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